Service 42A  City Centre - Mutley Plain - Crownhill - Derriford Hospital - Marjons - Southway - Tamerton Foliot
 
From Royal Parade via St Andrews Cross Roundabout, Exeter Street Viaduct, Charles Cross Roundabout, Charles Street, Drake Circus [Plymouth University/History Centre], North Hill, Mutley Plain, Mannamead Road, Manadon Roundabout, Tavistock Road [Crownhill Low Level], Derriford Roundabout, Derriford Road, Derriford Hospital, Derriford Roundabout, Powisland Drive, Tavistock Road [George Junction], Southway Drive [Southway Surgery], Southway Drive [Shops], Clittaford Road [Falstaff], Dunnet Road, Tamerton Foliot Road, Fore Street, Whitsoncross Lane, Linton Road and Linton Close to Cunningham Road Tamerton Foliot 
 
Service 42A  Tamerton Foliot - Southway - Marjons - Derriford Hospital - Crownhill - Mutley Plain - City Centre
 
From Cunningham Road Tamerton Foliot via Linton Close, Linton Road, Whitsoncross Lane, Fore Street, Tamerton Foliot Road, Dunnet Road, Clittaford Road [Falstaff], Southway Drive [Shops], Southway Drive [Southway Surgery], Tavistock Road [George Junction], Powisland Drive, Derriford Roundabout, Plymbridge Lane, Marjons Link Road,  Derriford Hospital, Derriford Road, Derriford Roundabout, Tavistock Road [Crownhill Low Level], Manadon Roundabout, Mannamead Road,  Mutley Plain, North Hill, Drake Circus [History Centre/Plymouth University], Cobourg Street, Mayflower Street, Western Approach, Union Street and Derrys Cross Roundabout to Royal Parade