Service 42  City Centre - Mutley Plain - Crownhill - Marjons - Derriford Hospital

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From Royal Parade via St Andrews Cross Roundabout, Exeter Street Viaduct, Charles Cross Roundabout, Charles Street, Drake Circus [Plymouth University/History Centre], North Hill, Mutley Plain, Mannamead Road, Manadon Roundabout, Tavistock Road [Crownhill Low Level], Derriford Roundabout, Derriford Road, Plymbridge Lane and Marjons Link Road to Derriford Hospital.

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Service 42  Derriford Hospital - Crownhill - Mutley Plain - City Centre

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From Derriford Hospital via Derriford Road, Derriford Roundabout, Tavistock Road [Crownhill Low Level], Manadon Roundabout, Mannamead Road,  Mutley Plain, North Hill, Drake Circus [History Centre/Plymouth University], Cobourg Street, Mayflower Street, Western Approach, Union Street and Derrys Cross Roundabout to Royal Parade

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Service 42C  City Centre - Mutley Plain - Crownhill - Derriford Hospital - Marjons - Woolwell

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From Royal Parade via St Andrews Cross Roundabout, Exeter Street Viaduct, Charles Cross Roundabout, Charles Street, Drake Circus [Plymouth University/History Centre], North Hill, Mutley Plain, Mannamead Road, Manadon Roundabout, Tavistock Road [Crownhill Low Level], Derriford Roundabout, Derriford Road, Derriford Hospital, Marjons Link Road, Plymbridge Lane, Runway Road, Tavistock Road [George Junction], Woolwell Roundabout and Woolwell Road [Tesco] to Woolwell Road [Church Park Drive].  

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Service 42C  Woolwell - Marjons - Derriford Hospital - Crownhill - Mutley Plain - City Centre

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From Woolwell Road [Church Park Drive] via Woolwell Road [Tesco], Woolwell Roundabout, Tavistock Road [George Junction], Runway Road, Plymbridge Lane, Marjons Link Road, Derriford Hospital, Derriford Road, Derriford Roundabout, Tavistock Road [Crownhill Low Level], Manadon Roundabout, Mannamead Road,  Mutley Plain, North Hill, Drake Circus [History Centre/Plymouth University], Cobourg Street, Mayflower Street, Western Approach, Union Street and Derrys Cross Roundabout to Royal Parade