City Centre - Derriford - Woolwell
 
Service 42  City Centre - Mutley Plain - Crownhill - Marjons - Derriford Hospital
 
From Royal Parade via St Andrews Cross Roundabout, Exeter Street Viaduct, Charles Cross Roundabout, Charles Street, Drake Circus [Plymouth University/History Centre], North Hill, Mutley Plain, Mannamead Road, Manadon Roundabout, Tavistock Road [Crownhill Low Level], Derriford Roundabout, Derriford Road, Plymbridge Lane and Marjons Link Road to Derriford Hospital.
 
Service 42  Derriford Hospital - Crownhill - Mutley Plain - City Centre
 
From Derriford Hospital via Derriford Road, Derriford Roundabout, Tavistock Road [Crownhill Low Level], Manadon Roundabout, Mannamead Road,  Mutley Plain, North Hill, Drake Circus [History Centre/Plymouth University], Cobourg Street, Mayflower Street, Western Approach, Union Street and Derrys Cross Roundabout to Royal Parade
 
Service 42C  City Centre - Mutley Plain - Crownhill - Derriford Hospital - Marjons - Woolwell
 
From Royal Parade via St Andrews Cross Roundabout, Exeter Street Viaduct, Charles Cross Roundabout, Charles Street, Drake Circus [Plymouth University/History Centre], North Hill, Mutley Plain, Mannamead Road, Manadon Roundabout, Tavistock Road [Crownhill Low Level], Derriford Roundabout, Derriford Road, Derriford Hospital, Marjons Link Road, Plymbridge Lane, Runway Road, Tavistock Road [George Junction], Woolwell Roundabout and Woolwell Road [Tesco] to Woolwell Road [School Drive], Pick Pie Drive to Woolwell [Church Park Road].  
 
Service 42C  Woolwell - Marjons - Derriford Hospital - Crownhill - Mutley Plain - City Centre
 
From Woolwell [Church Park Road] to Pick Pie Drive, Woolwell Road [School Drive] via Woolwell Road [Tesco], Woolwell Roundabout, Tavistock Road [George Junction], Runway Road, Plymbridge Lane, Marjons Link Road, Derriford Hospital, Derriford Road, Derriford Roundabout, Tavistock Road [Crownhill Low Level], Manadon Roundabout, Mannamead Road,  Mutley Plain, North Hill, Drake Circus [History Centre/Plymouth University], Cobourg Street, Mayflower Street, Western Approach, Union Street and Derrys Cross Roundabout to Royal Parade


City Centre - Derriford - Tamerton
 
Service 42A  City Centre - Mutley Plain - Crownhill - Derriford Hospital - Marjons - Southway - Tamerton Foliot
 
From Royal Parade via St Andrews Cross Roundabout, Exeter Street Viaduct, Charles Cross Roundabout, Charles Street, Drake Circus [Plymouth University/History Centre], North Hill, Mutley Plain, Mannamead Road, Manadon Roundabout, Tavistock Road [Crownhill Low Level], Derriford Roundabout, Derriford Road, Derriford Hospital, Derriford Roundabout, Powisland Drive, Tavistock Road [George Junction], Southway Drive [Southway Surgery], Southway Drive [Shops], Clittaford Road [Falstaff], Dunnet Road, Tamerton Foliot Road, Fore Street, Whitsoncross Lane, Linton Road and Linton Close to Cunningham Road Tamerton Foliot 
 
Service 42A  Tamerton Foliot - Southway - Marjons - Derriford Hospital - Crownhill - Mutley Plain - City Centre
 
From Cunningham Road Tamerton Foliot via Linton Close, Linton Road, Whitsoncross Lane, Fore Street, Tamerton Foliot Road, Dunnet Road, Clittaford Road [Falstaff], Southway Drive [Shops], Southway Drive [Southway Surgery], Tavistock Road [George Junction], Powisland Drive, Derriford Roundabout, Plymbridge Lane, Marjons Link Road,  Derriford Hospital, Derriford Road, Derriford Roundabout, Tavistock Road [Crownhill Low Level], Manadon Roundabout, Mannamead Road,  Mutley Plain, North Hill, Drake Circus [History Centre/Plymouth University], Cobourg Street, Mayflower Street, Western Approach, Union Street and Derrys Cross Roundabout to Royal Parade
 
Service 42B  City Centre - Mutley Plain - Crownhill - Derriford Hospital - Marjons - Looseleigh Lane - Tamerton Foliot
 
From Royal Parade via St Andrews Cross Roundabout, Exeter Street Viaduct, Charles Cross Roundabout, Charles Street, Drake Circus [Plymouth University/History Centre], North Hill, Mutley Plain, Mannamead Road, Manadon Roundabout, Tavistock Road [Crownhill Low Level], Derriford Roundabout, Derriford Road, Derriford Hospital, Marjons Link Road, Plymbridge Lane, Derriford Road, Derriford Roundabout, Looseleigh Lane, Tamerton Foliot Road, Fore Street, Whitsoncross Lane, Linton Road and Linton Close to Cunningham Road Tamerton Foliot 
 
Service 42A  Tamerton Foliot - Looseleigh Lane - Marjons - Derriford Hospital - Crownhill - Mutley Plain - City Centre
 
From Cunningham Road Tamerton Foliot via Linton Close, Linton Road, Whitsoncross Lane, Fore Street, Tamerton Foliot Road, Looseleigh Lane, Derriford Roundabout, Derriford Road, Plymbridge Lane, Marjons Link Road,  Derriford Hospital, Derriford Road, Derriford Roundabout, Tavistock Road [Crownhill Low Level], Manadon Roundabout, Mannamead Road,  Mutley Plain, North Hill, Drake Circus [History Centre/Plymouth University], Cobourg Street, Mayflower Street, Western Approach, Union Street and Derrys Cross Roundabout to Royal Parade